Maeda, T., Yamamoto, T., Isikawa, Y., Itoh, N. & Arase, S. Sanguisorba Officinalis Root Extract Has FGF-5 Inhibitory Activity and Reduces Hair Loss by Causing Prolongation of the Anagen Period. Nishinihon J. Dermatology 69, 81–86 (2007). Original article in Japanese https://www.jstage.jst.go.jp/article/nishinihonhifu/69/1/69_1_81/_article/-char/ja/ Using engineered cell lines in vitro Advangen’s scientists identified FGF5 inhibitory activity in several botanical extracts including Rosa multiflora and Sanguisorba officinalis. A topical solution of S. officinalis extract was tested in a double blind, randomised, placebo controlled trial of 39 individuals (males and females) suffering hair loss. After 4 months of use, participants in the topical S. officinalis treatment group had a significant reduction in shed hair (p<0.01) with a concurrent reduction in shed vellus hair (p<0.01). Hair growth rate was assessed by phototrichograms and was shown to be increased by 18% (p<0.01). The proportion of anagen follicles in treated individuals was increased by 10% (p<0.01). User surveys highlighted performance satisfaction, with >75% of the treatment group labelling the solution as at least somewhat effective vs. only 25% of the placebo group.